Calcium Sennoside

Calcium Sennoside

Sennoside extracted from Cassia Angustifolia Calcium sennoside is excellent natural laxative properties. A very flexible and effective ingredients for safe formulations. This is a very proven and time tested medicinal product.

The Herb

  • Sennosides
    Sennosides along with other anthraquinone like hydroxyanthracene glycosides are the derivatives of Senna leaves. In the traditional & modern routine of medicines they have been used as proven laxatives in a natural way.
  • Origin
    Native of Sudan and Arabia. Completely naturalized in Indian agro climatic conditions and is cultivated in southern India, Rajasthan, Gujarat and Kutch in western India.
  • Morphology
    The stem is erect, smooth, and pale green. It has long, spreading branches, bearing leaflets in four or five pairs, averaging an inch long. It is lanceolate or obviate, unequally oblique at the base, veins distinct on the under surface, brittle, greyish-green, of a faint, peculiar odour, and mucilaginous, sweetish taste. The form of the base, and freedom from bitterness, distinguish the Senna from the Argil leaves, which are also thicker and stiffer. The flowers are small and yellow. The pods are broadly oblong; about 2 inches long by 7/8 inch broad, and contain about six seeds.
  • Senna preparations
    Commercial Senna is prepared for use by garbling, or picking out the leaflets and rejecting the lead-stalks, impurities, and leaves of other plants. Good Senna may be known by the bright, fresh, yellowish green colour of the leaves, with a faint and peculiar odour rather like green tea, and a mucilaginous, sweetish, slightly bitter taste. It should be powdered only as wanted, because the powder absorbs moisture, becomes mouldy, and loses its value. Boiling destroys its virtues, unless it is in vacuum, or in a covered vessel.

Products

Active Pharmaceutical Ingredients:
Calcium Sennoside A&B 20%, 40% and 60% as per USP Grade.
Calcium Sennoside A&B 20%, 40% and 60% as per B. P. Grade.
Calcium Sennoside A&B 20%, 40% and 60% by HPLC Method.
Sennoside 80% as per USP Grade.
Leaf Powder contain more than 2% of Sennoside.
Raw Senna Herb : As such & in Powder form
Leaves of Different size grade.
Pods.
Stems.

Application

Medicinal Values

  • Senna is an excellent laxative.
  • Senna is employed in treating many other ailments like, anemia, typhoid, cholera, jaundice, rheumatism, gout, tumours, probably in leprosy, in splenic enlargement, foul breath and bronchitis.
  • It is also used in the treatment of amoebic dysentery and a mild liver stimulant.
  • Effective in constipation, thermogenic, cathartic, liver tonic, abdominal disorders, leucoderma, splenomegaly, hepatomegaly, dyspepsia, cough and skin disorders.
  • Sennoside acts on the lower bowel and is especially useful in improving / lightening constipation.

Pharmacology

  • It is a soft purgative because of the presence of ample Anthraquinone.
  • Senna is still used as the primary ingredient in certain commercial stimulant laxatives.
  • Senna is also the primary ingredient found in most “dieter’s teas”. The combination of acting as a stimulant which reduces a dieter’s appetite, and the laxative properties that cause food to move through their system before as many calories can be absorbed is a combination that can lead to rapid weight loss.
  • It increases the peristaltic movements of the colon by its local action upon the intestinal wall. Its active principle must pass out of the system in the secretions unaltered. The purgative effect is increased by the addition of pure bitters.

Principle Constituents

  • Senna acts as purgative and has active ingredients Anthraquinone derivatives and their glucosides. The latter are called Sennosides or senna glycosides. It increases the peristaltic movements of the colon.
  • The purgative constituents are closely allied to those of Aloes and Rhubarb, the activities of the drug being largely due to Anthraquinone derivatives and their glucosides. It contains Rhein, Rhein 8-glucoside, Rhein 8-diglucoside, 8-glucoside, kaempferol, aloe-emedin, Isorhamnetin, both free and as glucosides together with myricyl alcohol, Chrysophanic Acid, etc.
  • The ash amounts to about 8 per cent, consisting chiefly of earthy and ashy carbonates.

Quality

Quality of Product is achieved through a holistic system & processes. It is supported by QA process & ultra modern QC equipments with microbiological lab.

Cultivation

  • Raw material processed from control cultivation contract source.
  • Pesticides free cultivation.
  • Ensure complete heavy metal free material.

Storage Of Raw Material (RM)

  • Material stored in hygienic condition.
  • Ensure contamination free environment from foreign bodies and impurities.

GMP production process

  • GMP compliant Facility.
  • Pharma Grade equipments.
  • Production process according to Pharma Guidelines.
  • Production process handling without human contact.
  • AHU to manage air humidity & quality air conditioning systems to ensure hygienic conditions.
  • Quality assurance practices using policies guidelines for consistent quality of end product of world class.

Finishing, packaging and FG Storage

  • Product packages procedure to ensure contamination free product.
  • Use of controlled air handling environment.
  • Material stored in hygienic condition and procured from pharma grade supplier.
  • Polarization using fumigations pure as per standards.
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